CJC-1295 and Ipamorelin: two ways to poke the GH axis
The somatotropic axis is the chain of hypothalamic, pituitary, and peripheral signals that regulates growth hormone and IGF-1. Two of the most-studied research peptides in this category sit on different parts of that chain. CJC-1295 hits the GHRH receptor on the pituitary somatotroph. Ipamorelin hits the ghrelin receptor (GHS-R1a). Different mechanisms, different cell types, different downstream signaling.
That’s why a lot of laboratory protocols use them as a blend — not to compound an effect, but to study how dual-receptor engagement of the GH axis differs from single-receptor work in cell-model systems.
CJC-1295
CJC-1295 is a synthetic analog of growth hormone-releasing hormone, based on the bioactive 1-29 fragment of native human GHRH. There are two versions in circulation:
- CJC-1295 with DAC. The “drug affinity complex” modification binds serum albumin, extending plasma half-life in animal models from minutes to days.
- CJC-1295 No DAC. Lacks that modification. Cleared from plasma faster. Used in protocols where extended exposure isn’t the goal.
We supply No DAC as a 5 mg lyophilized vial.
Ipamorelin
Ipamorelin is a five-amino-acid synthetic peptide. It engages the ghrelin receptor selectively, meaning that in the published characterization work it doesn’t trigger the off-target receptors some earlier ghrelin mimetics did. That selectivity is why Ipamorelin shows up in mechanism-of-action studies of GHS-R1a more than older compounds. We supply it as a 10 mg lyophilized vial.
The blend
We sell the CJC-1295 / Ipamorelin blend in two strengths: 5 mg and 10 mg. Same composition either way; the strength refers to total peptide content per vial.
Quality
HPLC for purity (target ≥99%), mass spectrometry for identity, batch-specific Certificate of Analysis with every order. Lyophilized; reconstitute with bacteriostatic water for short-term laboratory use.
Compliance
Everything in this category ships under our Research Use Only Disclaimer. None of these peptides are FDA-approved for human or veterinary use, and we don’t sell them for any therapeutic purpose.