IGF-1 LR3 1MG
IGF-1 LR3 1MG
$148.00
IGF-1 LR3 is a modified version of insulin-like growth factor 1. The natural protein is 70 amino acids; the LR3 version adds a 13-amino-acid extension at the N-terminus and substitutes arginine for glutamic acid at position 3. Both modifications reduce its binding to IGF-binding proteins, which extends its half-life in cell-culture media. That’s the practical reason researchers use it instead of native IGF-1.
What ships: 1MG per vial · ≥99% HPLC-verified purity · MS-confirmed identity · batch-specific Certificate of Analysis.
| Quantity | You save | Per unit |
|---|---|---|
| 3+ | 5% | $140.60 |
| 5+ | 10% | $133.20 |
| 10+ | 15% | $125.80 |
Description
IGF-1 LR3 is a recombinant analog of human insulin-like growth factor 1 (IGF-1) carrying two modifications: an N-terminal 13-amino-acid extension and an arginine substitution at position 3. These modifications reduce binding to IGF-binding proteins (IGFBPs) and extend the plasma half-life relative to native IGF-1, making it a widely used tool compound in IGF receptor research.
Research Context
Preclinical investigations have used IGF-1 LR3 in cell-culture and rodent models examining IGF-1 receptor (IGF-1R) signaling, including downstream PI3K/Akt and MAPK pathway activation. Laboratory research has explored the compound in studies of cell proliferation, differentiation, and survival across multiple cell types including myoblasts, osteoblasts, and neuronal cultures. Researchers have also employed IGF-1 LR3 as a reference in structure-activity studies examining how modifications to IGFBP binding alter signaling kinetics relative to native IGF-1. The compound continues to be a fixture in IGF-axis research workflows due to its prolonged activity in cell-culture environments containing serum IGFBPs.
Reconstitution & Storage
- Recommended reconstitution: 1 mL bacteriostatic water per 1 mg vial
- Storage: Lyophilized: 2-8°C (refrigerated), long-term -20°C. Reconstituted: 2-8°C, use within 28 days.
- Stability: Avoid freeze-thaw cycles. Protect from light.
Quality Specifications
| Parameter | Specification |
|---|---|
| Purity | ≥99% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Form | Lyophilized powder |
| Vial size | 1 mg |
| COA | Included with order |
Research Use Only Disclaimer
This product is sold strictly for laboratory and scientific research purposes. Not for human consumption, ingestion, or administration. Not intended to diagnose, treat, cure, or prevent any disease. Not approved by the FDA for any clinical use.
Reviews
There are no reviews yet.