Semaglutide (GLP-1) 5MG
Semaglutide (GLP-1) 5MG
$45.00
Semaglutide is a synthetic version of GLP-1 (glucagon-like peptide-1). Native GLP-1 has a half-life of about two minutes in plasma, which makes it useless for any extended experiment. Semaglutide solves that with a couple of amino-acid substitutions and a fatty-acid side chain that lets it bind serum albumin and stick around. Labs use it in cell-model work on the GLP-1 receptor.
What ships: 5MG per vial · ≥99% HPLC-verified purity · MS-confirmed identity · batch-specific Certificate of Analysis.
| Quantity | You save | Per unit |
|---|---|---|
| 3+ | 5% | $42.75 |
| 5+ | 10% | $40.50 |
| 10+ | 15% | $38.25 |
Description
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1), structurally modified at residues 8 and 34 and conjugated to a C18 fatty di-acid side chain via a spacer. These modifications confer resistance to DPP-IV degradation and enable albumin binding, properties that have made the molecule a subject of extensive preclinical incretin research.
Research Context
Preclinical investigations have examined semaglutide as an agonist at the GLP-1 receptor, a class B G-protein-coupled receptor expressed across pancreatic, gastrointestinal, and central nervous system tissues in rodent and in vitro models. Laboratory research has explored the compound’s signaling profile, internalization kinetics, and downstream cAMP/PKA pathway activation. Researchers have used semaglutide in cell-culture and rodent metabolic research as a reference GLP-1 receptor agonist, often comparing its profile to other incretin analogs in structure-activity studies. The compound is provided here strictly as a research reagent for in vitro and preclinical metabolic biology workflows.
Reconstitution & Storage
- Recommended reconstitution: 2-3 mL bacteriostatic water per 5 mg vial
- Storage: Lyophilized: 2-8°C (refrigerated), long-term -20°C. Reconstituted: 2-8°C, use within 28 days.
- Stability: Avoid freeze-thaw cycles. Protect from light.
Quality Specifications
| Parameter | Specification |
|---|---|
| Purity | ≥99% (HPLC) |
| Identity | Confirmed by mass spectrometry |
| Form | Lyophilized powder |
| Vial size | 5 mg |
| COA | Included with order |
Research Use Only Disclaimer
This product is sold strictly for laboratory and scientific research purposes. Not for human consumption, ingestion, or administration. Not intended to diagnose, treat, cure, or prevent any disease. Not approved by the FDA for any clinical use.
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